NOT KNOWN FACTS ABOUT METHADONE FOR ALCOHOL WITHDRAWAL

[61] Like several other cardiotoxic drugs, methadone blocks the hERG K+ channel. The 2 enantiomers of methadone inhibit hERG channels with various potency. Dextromethadone, that is significantly less powerful being an opioid, is more strong at blocking the hERG channel with an IC50 of ~twelve μM. Levomethadone provides a lower affinity, with an IC